FAIL (the browser should render some flash content, not this).

Welcome to the Guimond lab
Lymphocyte Homeostasis and Regeneration of the Immune System.
Latest news


December 6th 2013
Dominique Leboeuf won the best scientific manuscript of the year at HMR.


June 6th 2013
Our paper intitulated "TCR triggering moduates the responsiveness and proiferation of CD4+ thymic emigrants" was pubisehd in the prestigious american journal "blood".


April 01th 2013
Simon-David Gauthier was awarded a scholarship from le "Fond de la Recherche du Quebec en Santé"


February 1st 2013
In collaboration with a team of the National Institutes of Health, Dr. Guimond published some seminal findings about graft-versus-host disease.


June 26th 2011
Simon-David Gauthier was awared a scholarship from the Cole Fundation.


June 20th 2011
Olga Honnion is presenting a scientific poster during the FOCIS meeting in Washington DC.


June 19th 2011
Tanguy Reny is a new summer student in our laboratory


April 15th 2011
Simon-David Gauthier was awared a CIHR award for his Master studies.


April 3rd 2001
Dr. Stephanie Thiant form Lille France joined our lab as a post-doctoral fellow.


Feb 12th 2011
Dr. Guimond is giving a plenary talk on T cell homeostasis during the annual meeting of the Canadian Society of Transplantation at Mont-Tremblant.

Jan 10th 2011
Philippe Laflamme has joined the Guimond's lab.

Our laboratory is composed of undergraduate and graduate students who are working to understand how T-cell regeneration occurs after Stem Cell Transplantation or other clinical settings of human lymphopenia. Our goal is to eventually develop treatments to accelerate the regeneration of the immune system in immunocompromized patients. During the past decade, there have been considerable progresses in understanding fundamental processes that regulate the recovery of the immune system post-Bone Marrow Transplantation or following high dose of chemotherapy. Recent insights into the biology of T-cell depletion have led to the discovery of new targets for therapy. Simultaneously, discoveries in immunology have led to the development of new biological reagents capable of regulating white blood cell homeostasis. The Guimond lab has developed a close partnership and collaboration with clinical scientists at the Maisonneuve-Rosemont Hospital in order to accelerate the translation of our lab 's discoveries into new therapies for patients. Efforts are made to:

Understand the basic science of T-cell depletion. Lymphocyte homeostasis is complex and a careful analysis of how naïve CD8+ and CD4+ T-cells are regenerated after T-cell depletion suggests that each subset posses their own niche that minimally overlap with each other. To accelerate the regeneration of the T-cell compartment of lymphopenic patients, we need to define the composition of the peripheral lymphoid niche that regulates CD4 and CD8 lymphocytes.
Understand the immunosuppression associated with Graft-Versus-Host Disease (GVHD). It is well known that the adverse effects of GVHD greatly exaggerates the immunosuppression normally associated with Hematopoietic Stem Cell Transplantation. As a result, transplanted patients experiencing GVHD are extremely vulnerable to infections and/or relapse due to lack of white blood cell recovery. Our lab is making efforts to understand the adverse effects of GVHD on the peripheral niche that regulates T-cell regeneration.
Identify strategies to decrease immunosuppression associated with cancer treatment and accelerate immune reconstitution. Lack of lymphocyte reconstitution represents a serious complication for many patients treated with high dose chemotherapy or following hematopoietic Stem Cell Transplantation. It is well known that in most clinical setting of human lymphopenia, CD4+ T lymphocytes will never recover to normal levels. We are working on pre-clinical models of human lymphopenia to experiment drugs or strategies that can be used to enhance T-cell regeneration. We are trying to modify the peripheral niche in order to augment Homeostatic Peripheral Expansion of low affinity CD4+ T cells. In addition, efforts are made to differentiate T lymphocytes in vitro in order to provide a potential new source of T lymphocytes to lymphopenic patients.



Interviews TV


Le code Chastenay : Percée importante dans la greffe de moelle osseuse.


4 mai 2009, Radio-Canada, Téléjournal. Reportage de Caroline Belley montrant les résultats exceptionnels des recherches menées dans le domaine des cellules souches.

12 janvier 2009, RDI, Simon Durivage. Entrevue avec le Dr Martin Guimond concernant sa découverte du mécanisme de régénération des lymphocytes T CD4+.


Interviews Press.


Journal La Presse : Le chercheur montréalais Martin Guimond découvre le mécanisme qui empêche la régénération d'un certain type de globules blancs essentiels au bon fonctionnement du système immunitaire.

Journal de Montréal : Un médecin exilé aux États-Unis rapatrié.

Site web Radio-Canada : Le système immunitaire contre-attaque.