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Welcome to the Guimond lab
Lymphocyte Homeostasis and Regeneration of the Immune System.
 

 


Latest news

December 6st 2013 Dominique Leboeuf won the best manuscrip competition at HMR research center.
  We are extremly proude to annouce that Dominique Leboeuf was in competition for the best manuscript at HMR Resarch center. With Olga Hennion, they succeeded to discover why regeneration of CD4+ T cells was less efficient than CD8+ T cells during IL-7 therapy. Martine Dupuis, Simon-David Gauthier and Stephanie Thiant were among the co-authors on this study. We would like to congratulate Dominique for the outstading presentation she did to defend our work.

June 6st 2013 Our paper intitulated "TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+ thymic emigrant to IL-7" was published by the prestigiour scientific magazin Blood.
  We are extremly proude of Olga Hennion and Donimic Leboeuf that conducted a study on the mechanism by which IL-7 regenerate white blood cells after stem cell transplantation. Here they discovered why CD4+ T cells responded pourly to IL-7 therapy. Essentially they found that TCR signalling was lower in the periphery compared to CD4 cells contained inside the thymus. As a result, IL-7 effectiveness is lowered in the periphery but surprisignly when lymphocytes were stimulated via their TCR, they responded more to IL-7 therapy. This is a seminal finding that may contribute to improve therapy aimed at regenerating T cells in patients undergoing stem cell transplantion. We would like to congratulate Olga and Dominic for their outstanding work. Martine Dupuis expert in Flow cytomety, Simon-David Gauthier, PhD student, and Sephanie Thiant Post-doctora fellow in Guimond-lab were co-authors on this study.

April 1st 2013 Simon-David Gauthier was awarded a scholarship from the "Fond de la Recherche du Quebec en Santé.
  We are happy to announce that Simon-David Gauthier was awarder a scholarship from the FRQS. Simon-David is a future researcher in leukemia and stem cell transplataiton. Very few sholarship are given for bright students in sciece. Simon-David is clearly one on the best graduate student we have at Maisonneuve-Rosemont Hospital. As a future superstar in reserch we are proud that Simon-David choose our lab to complete his training. This your researcher is hard working and comitted to find a cure for patients with leukemia and other cancers. we wish the best for Simon-David.

Februar 1st 2013 In collaboration with the National Institutes of Health, Dc. Guimond published seminal findint about "graft-versus-host disease.
  One of the best treatment for leukemia patients is bone marrow transplantation from a compatible donor. Unfortunately, immune cells fron the graft often attact and can kill the patient. In addition, graft-versus-host disease is immunosuppressive and lethal infections are commonly seen in patients. In this work, we demonstrated that anti-leukemia cells proliferation in constrained by graft-versus-host disease which may explain the occurence of infection during such disease. Future works will aimes to undserstant how immunosuppression occurs. If you would like to contribute to our research, please fell free to email or call me directly at our facility located at Maisonneuve-Rosemont Hospital 1-514-252-3400 (7624). I will be happy to discuss with you and tell you how you could contribute to our research. Thank you for our interest in our research.

Latest news

August 10 2011 The Cancer Research Society has ranked our resarch grant on Leukemia among the best in Canada.
  We are happy to announce that the Cancer Research Society (CRS) has ranked our research grant among the best in Canada and will be providing $120 000.00 for 2 years. This money will serve to study Graft-Versus-Host Disease and immune reconstitution in the setting of allogeneic stem cell transplantation. Hopital Maisonneuve-Rosemont is the largest center for hematopoietic stem cell transplantation in Quebec and the second in importance in Canada. Unfortunately immune reconstitution in leukemia patients is still extremely challenging with several patients dying every years. With CRS support, we hope to elucidate the mechanism that constrains white blood cell recovery in order to develop strategies to accelerate immune reconstitution in transplanted patients. We would like to thanks the CRS for their generous contribution to our research. If you are interested to contribute yourself to our research, please fell free to email or call directly at our facility located at Maisonneuve-Rosemont Hospital 1-514-252-3400 (7624). We are providing recite for income tax. To know more about the Cancer Resarch Society, please visit: www.src-crs.ca. The Cancer Research Society is entirely devoted to finance research on cancer.

June 26 2011 Simon-David Gauthier was awarder a followship for the Cole Foundation.
  For several years, the Cole Fundation has provided awards for outstanding students working in the field of pediatric cancers and leukemia. Simon-David Gauthiers is a master student working in the field of Hematopoietic Stem Cell Transplantation. Specifically, he is trying to understand the adverse effect of acute Graft-Versus-Host Disease on immune-reconstitution in leukemia patients recieving Bone Barrow Transplantation as curative treatment. Unfortunately, Graft-Versus-Host Disease worsen immune reconstitution and this is associated with high risk of leukemia relapse, infections and death. We are very confident that this work will provide valuable information about fundamental mechanisms that limit the recovery of white blood cells in the setting of Hematopoietic Stem Cell Transplantation and Graft-Versus-Host Disease. The goal of the Guimond's lab is to develop therapies that will contribute to cure leukemia or other solid tumors. We would like to thank the Cole Fundation for their contribution to our research. To know more about the Cole Fundation, please visit www.colesfoundation.org

June 20 2011 Olga Hennion is presenting a poster during the FOCIS meeting in Washington DC
  Olga Hennion is a master student trying to understand the mechanism by which IL-7 therapy works on immune reconstitution, specifically the regeneration of CD4+ T cells. She recently made a brake through by elucidating the mechanism by which IL-7 therapy expands Recent Thymic Emigrants. We are confident that this new information will help to develop strategies to augment the efficacy of IL-7 therapy to accelerate immune reconstitution after Bone Marrow Transplantation or following high dose chemotherapy as therapies to treat leukemia or other solid tumors. We whish Olga good luck.

June 19th 2011 We welcome to Tanguy Reny that joined our lab as sumer student.
  Tanguy Reny is a summer student currently enrolled at Jean de Breboeuf College in Montreal. One of the mission of the Guimond'lab is to train the next generation of young scientists in Quebec and Canada. For this purpose, we invite during summet students finishing High school (Fourth or Fifth grade) or College that are interested in biological science to join our laboratory. If you are interested by a training in biological sciences, pease email us or call directly at 514-252-3400 (7624)

April 15th 2011 Simon-David Gauthier was awarded a CIHR scholarship.
  We are pleased to announce that Simon-David Gauthier was awarded a CIHR fellowship. We would like to thank the CIHR for the support they provide to our students. The money provided by CIHR will contribute substantially to accelerate our program in regenerative medicine to develop therapies to patients with severe immune deficits.

April 3rd 2011 Dr. Stephanie Thiant joins the Guimond's lab.
  We are excited to announce that Dr. Stephanie Thiant has decided to join our laboratory as post-doctoral fellow. Dr. Thiant completed a PhD in immunology at University of Lille in France and she decided to join our laboratory to work on lymphocyte regeneration in the setting of Hematopoietic Stem Cell Transplantation. Dr. Thiant is an expert in human hematology and immunology. We welcome Dr. Thiant and we wish her good luck.

 


Feb 5th 2011 Simon David Gauthier will be presenting his work during the annual meeting of the Canadian Society of Transplantation in Mont Tremblant.
  Next week, Simon David will be at Mont-Tremblant to present his work on Graft-Versus-Host Disease and how alloreactivity disrupts the peripheral niche regulating T cell homeostasis. We wish him good luck.

Jan 10th 2011 Philipe Laflamme joined the Guimond Lab.
  We are very excited to announce that Philippe Laflamme has joined the Guimond's lab. Philippe is currently completing a BSc in Biochemistry at University of Quebec in Montreal. Philippe will be working on T cell regeneration in the setting of lymphopenia. Specifically, he will study how IL-7 signalling in DCs could be used to augment and accelerate lymphocyte regeneration in the setting of Hematopoietic Stem Cell Transplantation. We wish him good luck in his research.

May 14th 2010 Simon-David Gauthier has received the prestigious Dr. Gabriel-Marquis merit award.
  We are very proud to annouce that Simon-David Gauthier has received the prestigious Dr. Gabriel-Marquis merit award from the department of Microbiology-Immunology of the University of Montreal. This award is given once a year to one M.Sc. student based on the excellence of his grade. Simon-David is working on the effect of Graft-Versus-Host disease on the recovely of white blood cells. We would like to congratulate Simon-David.

May 6th 2010 Julien Chaumillon joined the Guimond Lab.
  We would like to welcome Julien Chaumillon that joined our lab as a summer student. Julien is an undergrad student currently enrolled in Biomedical Sciences. He will be working on the mechanism that regulates the expression of transplantation antigens (Major Histocompatibility Complexe Class II molecules) expressed by Antigen Presenting Cells. We wish him good luck with his summer project.

April 10th 2010 Dominique Leboeuf is the new Lab Manager of the Guimond's lab.
  We are excited to announce that Dominique Leboeuf is our new lab manager. Dominique graduated with honor at the University of Montreal in 2006. She recieved several distinctions during her training including le Fond de la Recherche en Sante du Quebec (FRSQ). Dominique will be working on how elevated IL-7 constrains white blool cells (CD4+) regeneration in lymphopenic patients. We wish her good luck.

March 15th 2010 The Cell Therapy Center will finance our research on the elucidation of the cell subset that regulates CD4 homeostasis.
  One goal of the Guimond's lab is to identify the type(s) of Antigen Presenting Cells that regulates the homeostasis of CD4+ T lymphocytes in order to use them to treat patients with severe lymphopenia. Using pre-clinical models, we do adoptive transfers of Antigen Presenting Cells into lymphopenic mice in order to determine which type of APC can positively affect CD4+ T cells. Each experiment is very costly but these pre-clinical studies are critical for the identification of the cell type(s) regulating this process in humans. We would like to thank the “Centre d’Excellence en Therapie Cellulaire of Maisonneuve-Rosemont Research Center” for helping with financial support to this project.

Feb 15th 2010 Our grant entitled "Regulation of Naïve CD4 T Cell Homeostasis During Lymphopenia" has received a positive approval from the Canadian Institute of Health Research.